Senior Principal Software Engineer

At Lilly, we unite caring with discovery to make life better for people around
the world. We are a global healthcare leader headquartered in Indianapolis,
Indiana. Our employees around the world work to discover and bring life-changing
medicines to those who need them, improve the understanding and management of
disease, and give back to our communities through philanthropy and volunteerism.
We give our best effort to our work, and we put people first. We’re looking for
people who are determined to make life better for people around the world. About
Lilly At Lilly, everything we do starts with patients. We unite caring with
discovery to make life better for people around the world. Headquartered in
Indianapolis, Indiana, our global team of over 50,000 employees work with
urgency and purpose to discover and deliver life-changing medicines, strengthen
how health is understood and managed, and support the communities we serve. We
bring our best to this work because people depend on it. If you’re driven by
purpose and determined to make a meaningful difference for patients, we invite
you to bring your skill and your commitment to Lilly. About Tech@Lilly At Lilly,
technology is not a support function. It is how a global medicine company
operates, innovates, and delivers. Lilly in India builds the capabilities that
make this possible, cloud platforms, AI systems, and automation at enterprise
scale, all in service of a purpose that makes this technology work genuinely
distinctive, from advancing drug discovery to enabling connected clinical trials
to keeping a global medicine company running at the standard patients deserve.
R-103615 – Senior Principal Software Engineer About the Technology Organization
Technology at Lilly builds and maintains capabilities using pioneering
technologies like most prominent tech companies. What differentiates Technology
at Lilly is that we create new possibilities through tech to advance our
purpose, creating medicines that make life better for people around the world,
like data driven drug discovery and connected clinical trials. We hire the best
technology professionals from a variety of backgrounds, so they can bring an
assortment of knowledge, skills, and diverse thinking to deliver solutions in
every area of our business. About the Business Function The Software Product
Engineering (SPE) team is a specialized engineering group that delivers
strategic solutions and differentiated capabilities. We take a forward-thinking
approach, focusing on an enterprise platform and product mindset, ensuring that
the solutions we build can be leveraged across Technology teams for broader
impact and efficiency. Role Summary We are looking for a passionate and driven
Software Engineer to join our AI & Platform team. In this role, you will design,
build, and scale intelligent systems that leverage the latest advances in
Generative AI and Large Language Models. You will work closely with product,
data science, and infrastructure teams to deliver robust, production-grade
solutions that power real-world use cases across the organization. You should be
comfortable working across the stack, from crafting clean backend services to
contributing to frontend experiences and be excited about the rapidly evolving
landscape of agentic AI, model-context protocols, and cloud-native architecture.
What You’ll Be Doing 1) Key Responsibilities Architect and lead the delivery of
scalable, cloud-native software systems across backend and frontend layers. Own
end-to-end design and implementation of GenAl and LLM-powered platform
capabilities in production. Design and govern multi-agent Al architectures using
MCP, A2A, and emerging agentic frameworks. Define containerisation,
orchestration, and deployment standards using Docker, Kubernetes, and Helm. Lead
architectural reviews, establish engineering best practices, and set technical
direction for the team. Drive cross-functional technical collaboration with
product, data science, security, and infrastructure teams. Identify and resolve
systemic technical risks across services, APIs, and data pipelines. Mentor
junior engineers through pairing, code reviews, and structured knowledge
transfer. Champion observability, reliability, and security practices across the
platform. Familiarity with Agentic AI/Multi Agent orchestration frameworks like
OpenAI agents SDK, LangGraph, etc is desired Experience with workflow management
tools like Temporal, Airflow 2) Required Qualifications Hands-on experience with
at least one programming language: Python, Go, or TypeScript Experience building
or integrating Generative AI or LLM-based solutions Understanding of
object-oriented design principles and common design patterns Familiarity with
agentic AI concepts and frameworks (MCP, A2A, or similar) Experience with Docker
and container-based development Working knowledge of cloud platforms such as
AWS, Azure, or GCP Experience with both SQL and NoSQL databases Strong
analytical and problem-solving skills Experience with frameworks such as React,
Next.js, or FastAPI Knowledge of microservices and distributed system design
Experience with BDD or TDD practices Familiarity with authentication and
authorization mechanisms (OAuth, JWT, SAML, etc.) Exposure to Kubernetes or
container orchestration platforms Experience working in Agile/Scrum delivery
models 3) AI-Enhanced Development Leverage AI tools like GitHub Copilot, claude
code to accelerate development workflows, improve code quality, and reduce
boilerplate Demonstrate proficiency in prompt engineering to effectively guide
AI tools in generating optimal and context-aware code solutions Use AI-assisted
pair programming to support rapid prototyping, test case generation, and
debugging Stay informed about the evolving landscape of AI-powered development
tools and integrate best practices into day-to-day engineering work Encourage
and mentor team members on responsible and secure use of AI in the software
development lifecycle 4) Basic Qualifications Bachelor’s degree in computer
science or a related technical field. 10+ years of hands-on software development
experience across frontend and backend systems. Demonstrated ability to lead
code reviews, guide junior engineers, and build production-grade software.
Strong foundation in computer science fundamentals, software architecture, and
cloud-native patterns 5) Soft Skills Effective verbal and written communication
skills Ability to work collaboratively across backend, frontend, DevOps, and
product teams A high degree of intellectual curiosity and commitment to
continuous learning At Lilly, caring is not only what we do for patients. It is
how we work. We believe the people who dedicate themselves to making medicines
better deserve an environment that makes their lives better too, one where they
are supported, respected, and given the space to do their best work. This is not
just a policy. It is who we are. Lilly is dedicated to helping individuals with
disabilities to actively engage in the workforce, ensuring equal opportunities
when vying for positions. If you require accommodation to submit a resume for a
position at Lilly, please complete the accommodation request form
(https://careers.lilly.com/us/en/workplace-accommodation) for further
assistance. Please note this is for individuals to request an accommodation as
part of the application process and any other correspondence will not receive a
response. Lilly does not discriminate on the basis of age, race, color,
religion, gender, sexual orientation, gender identity, gender expression,
national origin, protected veteran status, disability or any other legally
protected status. #WeAreLilly At Lilly we strive to ensure our employees are
part of a team that cares about them and our shared purpose of making life
better for those around the world. How do we do this? We continue to look for
ways to include, innovate, accelerate and deliver while maintaining integrity,
excellence and respect for people. We hope that you seek to join us on our
journey as we create medicine and deliver improved outcomes for patients across
the globe! #WeAreLilly